Nanog (pronounced nanOg) is a transcription factor critically involved with self-renewal of undifferentiated embryonic stem cells. In humans, this protein is encoded by the NANOG gene.
Biodegradable micro- and nanospheres (MS, NS) made of poly(lactide-coglycolide) (PLGA) or other materials are very potent drug and antigen delivery systems with inherent potential for drug and antigen targeting. Present methods to produce PLGA NS are typical batch processes and suffer from difficulties of upscaling under sterile conditions. Here, we present a novel and elegant method to produce PLGA NS in a continuous, contact- and contamination-free process that can be readily run under sterile conditions. During the entire manufacturing process, the product is in direct contact only with sterile glass and Teflon® tubes. The process can be run in a closed system to prevent any environmental contamination.
Neural Stem Cell:
A type of stem cell that resides in the brain, which can make new nerve cells (called neurons) and other cells that support nerve cells (called glia). In the adult, neural stem cells can be found in very specific and very small areas of the brain where replacement of nerve cells is seen.
A technique in which an egg has its original nucleus removed and exchanged for the nucleus of a donor cell. The egg now has the same nuclear DNA, or genetic material, as the donor cell. Nuclear transfer is also referred to as somatic cell nuclear transfer (SCNT), as the donor cell is usually a somatic cell (that is, any cell of the body except sperm and egg cells). For additional information: Nuclear Transfer
A part of the cell, situated more or less in the middle of the cell, that is surrounded by a specialized membrane and contains the DNA of the cell. This DNA is packaged into structures called chromosomes, which is the genetic, inherited material of cells.